Synthesis, characterization, single crystal XRD, in vitro antimicrobial and cytotoxicity study of tris(ethylenediamine)cobalt(III)chloride oxalate trihydrate
Arabian Journal of Chemistry
The complex tris(ethylenediamine)cobalt(III)chloride oxalate trihydrate [Co(en) 3 ] Cl(C 2 O 4 )AE3H 2 O crystallizes in the monoclinic space group C 2 /c with the following unit cell parameters a = 19.9318 (13), b = 9.3344 (4), c = 19.0881 (13) Å b = 96.846(3)°, Z = 8. The crystal structure was solved by direct methods and refined by full matrix least squares procedures to a final R value of 0.0314 for 4330 observed reflections. The reported cobalt complex is six co-ordinated through amine
... d through amine nitrogen with distorted octahedral geometry. There are uncoordinated chloride and oxalate ions along with the water molecules. In-vitro antimicrobial activity was studied against various test organisms and found to be good. From in-vitro cytotoxic activity of the synthesized complex, the IC 50 value was found to be 55.85 lg/ml. ª 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).