Synthesis, characterization, single crystal XRD, in vitro antimicrobial and cytotoxicity study of tris(ethylenediamine)cobalt(III)chloride oxalate trihydrate

S. Jone Kirubavathy, R. Velmurugan, K. Parameswari, S. Chitra
2014 Arabian Journal of Chemistry  
The complex tris(ethylenediamine)cobalt(III)chloride oxalate trihydrate [Co(en) 3 ] Cl(C 2 O 4 )AE3H 2 O crystallizes in the monoclinic space group C 2 /c with the following unit cell parameters a = 19.9318 (13), b = 9.3344 (4), c = 19.0881 (13) Å b = 96.846(3)°, Z = 8. The crystal structure was solved by direct methods and refined by full matrix least squares procedures to a final R value of 0.0314 for 4330 observed reflections. The reported cobalt complex is six co-ordinated through amine
more » ... d through amine nitrogen with distorted octahedral geometry. There are uncoordinated chloride and oxalate ions along with the water molecules. In-vitro antimicrobial activity was studied against various test organisms and found to be good. From in-vitro cytotoxic activity of the synthesized complex, the IC 50 value was found to be 55.85 lg/ml. ª 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
doi:10.1016/j.arabjc.2014.10.013 fatcat:om3vftg3vjhtdnapugev2xt4wi