This study was designed to investigate the comparison of effects of low-dose unitrexate in neuropathological disorders in Pakistan. This cross sectional study was conducted in BVH, Bahawalpur during February 2019 to October 2019. This study was done according to the ethical committee of university and hospitals and all the protocols were reviewed by the committee. A total of 100 patients were selected for study who was suffering from any neurological disorder and use these type of drugs. The

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... dy was further divided into further groups. The variations between the mean values of MPO levels were significant according to the ANOVA and t-test. There were significant difference between control groups and treated groups. The data shows that the group of patients which was treated with both MTX and MP as a combine effect shows more close values to the control. But the separate effect shows somehow different values as compared to control. Low dose unitrexate is more effective as compared to methylprednisolone in neurological disorders.