Internet Archive Scholar

Effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants

Brenda B Poindexter, Richard A Ehrenkranz, Barbara J Stoll, Matthew A Koch, Linda L Wright, William Oh, Lu-Ann Papile, Charles R Bauer, Waldemar A Carlo, Edward F Donovan, Avroy A Fanaroff, Sheldon B Korones (+5 others)
2003 American Journal of Clinical Nutrition  

Preserved Fulltext

fulltext thumbnail
Web Archive Capture PDF (93.4 kB)
https://web.archive.org/web/20180728134945/https://watermark.silverchair.com/737.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAZ8wggGbBgkqhkiG9w0BBwagggGMMIIBiAIBADCCAYEGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMVaCXpLYYSzH-4FGtAgEQgIIBUidVPQzWKCC5XNtoQ3UMR5y-lYepEEcGeQK_X4tvLJcRvAiFidPdob5qK0E095atsmWGM22DTbQAtfj1Xj8VvWw8d46NfjC8ecPsR6hRESgukMqNMq2aGTsC56bSOdXl4wEB8ak6Rjw82r77S85_NJ4jwlVgsr1o98QKouCKY4Oe7PABQ5VwwhTe8LVfnnETjajgqkDlUW6L4X5GFtGPXkQVJEOfU6VRxSeomIk3_xk1ix4mDFSrgrK7tvwYUFkeBGhylF5aI4-RqmV0XCBU1hAxMkh92Jc_bQcRYO_K_mvC1x20sQ03y0JzMinj01YzVyjWJekSrj5NGegli-R_vhCg0NZ8zBT_NCmBYxX6iLGPKnFPvs_4H_k9nZBu_wMtVvnUyB9RQiUwBgEdnjO6OhEOv_YhuiAPAqREESuZGyMvVa7TbMO4H8qXgCHLSWaqBHP5

A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL. The file type is application/pdf.

Glutamine is one of the most abundant amino acids in both plasma and human milk and may be conditionally essential in premature infants. However, glutamine is not provided by standard intravenous amino acid solutions. Objective: We assessed the effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants receiving parenteral nutrition (PN). Design: A total of 141 infants with birth weights of 401-1000 g were randomly assigned to
more » ... a standard intravenous amino acid solution that did not contain glutamine or an isonitrogenous amino acid solution with 20% of the total amino acids as glutamine. Blood samples were obtained just before initiation of study PN and again after the infants had received study PN (mean intake: 2.3 ± 1.0 g amino acids · kg Ϫ1 · d Ϫ1 ) for Ϸ10 d. Results: Infants randomly assigned to receive glutamine had mean plasma glutamine concentrations that increased significantly and were Ϸ30% higher than those in the control group in response to PN (425 ± 182 and 332 ± 148 mol/L for the glutamine and control groups, respectively). There was no significant difference between the 2 groups in the relative change in plasma glutamate concentration between the baseline and PN samples. In both groups, there were significant decreases in plasma phenylalanine and tyrosine between the baseline and PN samples; the decrease in tyrosine was greater in the group that received glutamine. Conclusions: In extremely low-birth-weight infants, parenteral glutamine supplementation can increase plasma glutamine concentrations without apparent biochemical risk. Currently available amino acid solutions are likely to be suboptimal in their supply of phenylalanine, tyrosine, or both for these infants. Am J Clin Nutr 2003;77:737-43.
doi:10.1093/ajcn/77.3.737 pmid:12600870 fatcat:zrvz5ot46vapxavc4ifacnvf44
Citation

Brenda B Poindexter, Richard A Ehrenkranz, Barbara J Stoll, Matthew A Koch, Linda L Wright, William Oh, Lu-Ann Papile, Charles R Bauer, Waldemar A Carlo, Edward F Donovan, Avroy A Fanaroff, Sheldon B Korones, Abbot R Laptook, Seetha Shankaran, David K Stevenson, Jon E Tyson, James A Lemons. "Effect of parenteral glutamine supplementation on plasma amino acid concentrations in extremely low-birth-weight infants." American Journal of Clinical Nutrition 77.3 (2003) 737-743