PRACTICAL ISSUES OF THE ALCOHOL QUESTION,

1919 The Lancet  
256 enteritis. The reactions to the Gram-staining method of these various forms appear to be very variable, and this peculiarity was also to be observed in the cultures made on various media from the sputum. These cultures also gave interesting and suggestive results when examined under the microscope, as they, too, showed pleiomorphic characters. Although Dr. Beaumont used the various media suggested as specially adapted to the growth of the Pfeiffer bacillus, he was not able to isolate it. He
more » ... e to isolate it. He sometimes obtained single colonies which showed characters resembling the Pfeiffer organism, but they were never pure and often contained Gram-positive coccal elements; moreover the Pfeiffer-like organisms would often disappear in subculture. Dr. Beaumont has in addition made a few observations on the urine and blood in cases of influenza, and in the former he has obtained all the stages of the parasite he describes. In the blood in primary cultures he has recovered several of the stages or forms, but only in one case was he able to obtain growths in subculture. Dr. Beaumont's observations are admittedly incomplete, but they are sufficiently striking and suggestive to require further examination at the hands of other workers. If his results are I confirmed and the organism is submitted to and fulfils the full tests of the Koch postulates, then the relation of the various forms of the parasite to one another and to the different organisms found in this disease by other observers will afford interesting matters for investigation and possibly serve, as Dr. Beaumont suggests, to clear up the confusion at present existing by explaining the discrepancies and coordinating the divergent views. reports show the important differences between the effects produced by alcohol when taken with or without food, a question which we have pointed out again and again has a practical bearing, and which, Dr. Vernon now remarks, has been curiously ignored by most previous investigators. The Medical Research Committee agrees that the relations between the consumption of food and the physiological effects of absorbed alcohol are so important (as these recent studies show) that much previous work upon the effects of alcohol is now seen to have been impaired in value by disregard of the presence or absence of food in the stomach during the experiments. The influence of alcohol on manual work and on neuro-muscular coordination was investigated in eight men and five women. In seven of the subjects observations were
doi:10.1016/s0140-6736(01)48621-1 fatcat:xugd2lifqne6tfr3ybkb7i7buu