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The paper justifies a set of theoretical and methodological propositions and practical guidelines for the establishment and development of spatial economic structures in a region. These structures should be based on the improved system of tools, methods and management for the interaction and performance of business structures. Besides, the authors argue the appropriateness of the regional center of advanced social and economic development (CASED) and test the method for the optimizationdoi:10.5901/mjss.2015.v6n5s2p415 fatcat:f6z2iyjq45fa3hok5ao6l2ahgq