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A B S T R A C T Intravesical drug administration is used to deliver cytotoxic agents through a catheter to treat bladder cancer. One major limitation of this approach is poor retention of the drug in the bladder due to periodic urine voiding. Mucoadhesive dosage forms thus offer significant potential to improve drug retention in the bladder. Here, we investigate thiolated silica nanoparticles retention on porcine bladder mucosa in vitro, quantified through Wash Out 50 (WO 50 ) values, defineddoi:10.1016/j.ijpharm.2016.08.026 pmid:27530813 fatcat:3phkxos3orfx5cld6wvsnmtoba