WASP Wiskott-Aldrich syndrome protein family WHO World Health Organization Wisko wiskostatin WT wild-type XDR extensive drug resistant ZN Ziehl-Neelsen / Methylene blue zVAD zVAD.fmk 3-MA 3-methyladenine 4E-BP1 eukaryotic initiation factor 4E-binding protein 1 human disease have emerged. The so-called ancestral lineage of is more closely related to M. marinum and causes only sporadic disease in China, Japan, Mexico and South America. In contrast, BU in Africa, Australia and South East Asia is

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... imarily caused by the classical lineage of M. ulcerans containing the most pathogenic genotypes, resulting in a higher prevalence in these countries [24]. Strains of these two lineages are, together