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Clinical trials in neurovirology illustrate the special challenges confronting investigators planning to study these conditions, as well as the contributions of successful trials in establishing appropriate management for these devastating diseases. This article reviews key examples of progress in neurovirology that have been spurred by clinical trials, emphasizing human herpes virus encephalitis, HIV, and JC virus. Clinical trials in the setting of neurovirological diseases are characterizeddoi:10.1007/s13311-016-0440-8 pmid:27194073 pmcid:PMC4965408 fatcat:la5yaw6fpvevnejzubu43hatdy