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Our research focuses on the development of two cooperative approaches for resolution of the multi-item capacitated lot-sizing problems with time windows and setup times (MICLSP-TW-ST). In this paper we combine variable neighborhood search and accurate mixed integer programming (VNS-MIP) to solve MICLSP-TW-ST. It concerns so a particularly important and difficult problem in production planning. This problem is NP-hard in the strong sense. Moreover, it is very difficult to solve with an exactdoi:10.4236/ajor.2017.72006 fatcat:a5ipdohturhbzebhgajh227ogi