Introduction Bronchial thermoplasty is a licensed non-pharmacological treatment for severe asthma. Area covered This article considers evidence for the efficacy and safety of bronchial thermoplasty from clinical trials and observational studies in clinical practice. Its place in the management of severe asthma, predictors of response and mechanisms of action are reviewed. Expert commentary Bronchial thermoplasty improves quality of life and reduces exacerbations in moderate to severe asthma.

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... bidity from asthma is increased during treatment. Overall, patients treated in clinical practice have worse baseline characteristics and comparable clinical outcomes to trial data. Follow-up studies provide reassurance on long-term safety. Despite some progress, future 3 research needs to investigate uncertainties about predictors of response, mechanism of action and place in management of asthma. Word count: 121 words