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Effect of Systemic Nitric Oxide Synthase Inhibition on Optic Disc Oxygen Partial Pressure in Normoxia and in Hypercapnia
2009
Investigative Ophthalmology and Visual Science
PURPOSE. To investigate the effect of systemic nitric oxide synthase (NOS) inhibition on optic disc oxygen partial pressure (PO 2 ) in normoxia and hypercapnia. METHODS. Intervascular optic disc PO 2 was measured in 12 anesthetized minipigs by using oxygen-sensitive microelectrodes placed Ͻ50 m from the optic disc. PO 2 was measured continuously during 10 minutes under normoxia, hyperoxia (100% O 2 ), carbogen breathing (95% O 2 , 5% CO 2 ), and hypercapnia (increased inhaled CO 2 ).
doi:10.1167/iovs.08-2413
pmid:18676634
fatcat:rvkcoe6n35ac5kpo4hrh3zm6rm