Objective: To study the effect of fat-soluble vitamins combined with antibiotic therapy on serum indexes and pulmonary function of acute infantile mycoplasma pneumoniae infection. Methods: A total of 124 children with mycoplasma pneumoniae pneumonia treated in our hospital between May 2014 and March 2016 were selected as the research subjects and randomly divided into two groups, vitamin group received fat-soluble vitamins combined with antibiotic therapy and control group accepted routine

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... iotic therapy. 4 weeks after treatment, serum was collected and the kits were used to detect the content of inflammatory cytokines and antioxidants, and spirometer was used on the same day to detect lung function parameters. Results: Serum ICAM-1, IL-5, IL-17A, IL-18 and TNF-毩 content of vitamin group after treatment were significantly lower than those before treatment while CAT, MPO, SOD and GSH-Px content were significantly higher than those before treatment; serum ICAM-1, IL-5, IL-17A, IL-18, TNF-α, CAT, MPO, SOD and GSH-Px content of control group after treatment were significantly lower than those before treatment; after treatment, serum ICAM-1, IL-5, IL-17A, IL-18 and TNF-α content of vitamin group were significantly lower than those of control group while CAT, MPO, SOD and GSH-Px content were significantly higher than those of control group, and lung function parameters FVC, FEV1, PEF, FEF25, FEF50 and FEF75 were significantly higher than those of control group. Conclusion: The fat-soluble vitamins combined with antibiotic treatment of acute infantile mycoplasma pneumoniae infection can inhibit inflammation and oxidative stress, and improve lung function.