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Amyloid-β and Hyperphosphorylated Tau in the Prediction of Alzheimer's Disease
European Neurological Review
Brain amyloid-β (Aβ) deposition is widely believed to be an early event in Alzheimer's disease (AD). Aβ plaques, along with intracellular neurofibrillary tangles, which largely comprise hyperphosphorylated tau (HPτ), are considered to be neuropathological hallmarks of AD. Brain biopsies from living subjects could be used to evaluate these findings. It is possible to obtain biopsies from patients with presumed normal pressure hydrocephalus during diagnostic or shunt procedures. The presence ofdoi:10.17925/enr.2011.06.02.84 fatcat:hcegkofwvvffpk4tb2txlz3vzm