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Eight years' experience of an extended-interval dosing protocol for gentamicin in neonates
2009
Journal of Antimicrobial Chemotherapy
Dosing of gentamicin in neonates in Christchurch has been carried out since 2000 using a locally developed extended-interval dosing protocol. All dosing data have been recorded in a database. Aims: The aims of this study were to analyse the database to determine what percentage of neonates achieved target values for C max , C min and AUC, and to use the pharmacokinetic values of gentamicin to simulate new dosing protocols. Methods: C max , C min and AUC were compared with target values.
doi:10.1093/jac/dkp073
pmid:19299469
fatcat:eudhcn6ymjbrrpklmv25pfnbw4