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Accurate estimation of single cell allele-specific gene expression using all reads and combining information across cells
[article]
2018
bioRxiv
pre-print
Single-cell RNA sequencing (scRNA-Seq) can reveal features of cellular gene expression that cannot be observed in whole-tissue analysis. Allele-specific expression in single cells can provide an even richer picture of the stochastic and dynamic features of gene expression. Single-cell technologies are moving toward sequencing larger numbers of cells with low depth of coverage per cell. Low coverage results in increased sampling variability and frequent occurrence of zero counts for genes that
doi:10.1101/383224
fatcat:5rzeqg37zvg7hnqarkvwavjqri