A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf
.
Blind exploration of the unreferenced transcriptome reveals novel RNAs for prostate cancer diagnosis
[article]
2019
bioRxiv
pre-print
The broad use of RNA-sequencing technologies held a promise of improved diagnostic tools based on comprehensive transcript sets. However, mining human transcriptome data for disease biomarkers in clinical specimens is restricted by the limited power of conventional reference-based protocols relying on uniquely mapped reads and transcript annotations. Here, we implemented a blind reference-free computational protocol, DE-kupl, to directly infer RNA variations of any origin, including yet
doi:10.1101/644104
fatcat:iy4memuuuvgbxh2lfxqbkzgzna