Valproate antinociceptive and anti-inflammatory effect in female rodents [post]

Karolinne S Figueiredo, Maria LAO Sales, Juvenia B Fontenele, Glauce SB Viana, Francisco H Felix
2015 unpublished
Valproate, an indirect γ-aminobutiric acid agonist has been successfully used in various painful conditions. Despite its frequent use, limited pre-clinical and clinical data exist about its analgesic effect. We tested valproate p.o. in increasing doses (10, 25, 50, 100 mg/kg) in acute nociception models in mice (writhing test and formalin licking-paw test) and in acute primary thermal hyperalgesia induced by carrageenan in rats, comparing its effects to a non-treated control and morphine (5
more » ... and morphine (5 mg/kg), amitriptyline (10 mg/kg) or indomethacin (10 mg/kg). Valproate showed a statiscally significant (p<0.001) dose-response effect in these models, both in male and female mice and in female rats. Antihyperalgesic effect of valproate in the plantar model was not reverted by reserpine pre-treatment. Interestingly, the maximum effect of valproate on this model occurred at a dose of 50mg/kg and the higher dose of 100mg/kg showed a minor effect. Additionally, we demonstrated that valproate has anti-inflammatory effect in the carrageenan-induced oedema model in male and female mice. Valproate antinociceptive and anti-inflammatory effects seem not to be gender-specific in animal models.
doi:10.7287/peerj.preprints.1613v1 fatcat:jjvdsqb7urawtpbkncuvjdleoa