Frequency of Antibiotic Resistance among Group BStreptococcusIsolated from Healthy College Students

Shannon D. Manning, Mark D. Pearlman, Patricia Tallman, Carl L. Pierson, Betsy Foxman
2001 Clinical Infectious Diseases  
We report resistant rates to erythromycin and clindamycin among Streptococcus agalactiae (group B Streptococcus) isolated from a random sample of healthy male and nonpregnant female college students. Observed resistance rates were twice as high as those reported among pregnant women from the same geographic area 2 years prior. The incidence of Streptococcus agalactiae, or group B Streptococcus (GBS) infection, the leading cause of neonatal sepsis and meningitis [1], has decreased by 65% since
more » ... ased by 65% since the implementation of an intrapartum chemoprophylactic prevention program [2], from 1.7 to 0.6 cases per 1000 live births [3] . GBS remains universally susceptible to the first-line chemoprophylactic agents penicillin and ampicillin. However, resistance rates for clindamycin or erythromycin, which is recommended for women reporting a history of penicillin allergy who require GBS prophylaxis [2], range from 9% to 19% for erythromycin and 2% to 15% for clindamycin in the United States [4]. Other countries have reported even higher rates [5, 6] . To gain insight on antibiotic resistance rates in future pregnant populations, we describe resistance rates among GBS isolated from a random sample of healthy male and nonpregnant female college students not seeking medical care or treatment. Materials and methods. A total of 300 University of Mich-
doi:10.1086/324588 pmid:11698992 fatcat:6ai45vheoffvlalhkssrivrtju