Various researchers studied the nephrotoxicity of inhalational anesthetics, with contradictory results. We aimed to observe the impact of the repeated iso lurane or sevo lurane anesthesia on kidney structure and function. 40 female rats were used in this study. Animals were divided in 8 groups. Two groups served as control: IM (iso lurane) and SM (sevo lurane), exposed to oxygen alone (1l/min) 3 times, for 2 hours, every other day. Three groups were anesthetized with iso lurane (I1, I2, I3) and

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... the other three (S1, S2, S3) with sevo lurane. The anesthetics were administered three times, for two hours long each, every other day. Rats were sacri iced through cervical dislocation as follows: groups IM, SM, I1, S1 imediately after the last anesthesia, groups I2, S2 -6 hours post-anesthesia and groups I3, S3 -24 hours post-anesthesia. Kidney samples were harvested, ixed in 10% buffered formaline, embedded in paraf in, sectioned (5 μm thickness) and stained with Goldner's trichrome metod. After iso lurane anesthesia, the kidney displays a moderate congestion in the corticomedullary area, which maintains throughout the experimental period. The only changes in animals anesthetized with sevo lurane also appear on the vascular component. The congestion maintains throughout the experimental period in the renal cortex, as well as the corticomedullary area. No other aspects that suggest functional impairment are observed, in any of the experimental groups. Inhalational anesthesia with iso lurane and sevo lurane produces a moderate congestion, without majorly impairing the kidney function.