Anjali Jayakumar, Sharath Kumar D Shah, Suma K R
2018 Journal of Evolution of Medical and Dental Sciences  
BACKGROUND Hypothyroidism is a metabolic disorder with a cluster of clinical signs and symptoms, especially in middle-aged women. Spectrum of cardiovascular manifestation includes hypertension and dyslipidaemia, which are major causes of atherosclerosis and coronary artery disease. Altered lipid profile is a major expression in overt hypothyroidism according to many previous studies. We have established the relationship in subclinical hypothyroidism. Aim and Objective-1. The aim of this study
more » ... to improve the ability to diagnose unsuspected dyslipidaemia, especially in subclinical hypothyroidism to reduce further morbidity. 2. The objective of this study is to assess and compare varying degree of dyslipidaemia in subclinical and overt hypothyroidism patients. MATERIALS AND METHODS This is a descriptive study. The present study was carried out in the Department of General Medicine at Sri Siddhartha Medical College, Tumkur, Karnataka, with 100 patients (50 subclinical hypothyroidism and 50 overt hypothyroidism patients). Thyroid Profile was done with CLIA (chemiluminescence immunoassay) system. Lipid Profile was done with semi-automated analyser. RESULTS In the present study, the mean total cholesterol values were 195.2 ± 42.27 and 180.76 ± 41.32; Triglycerides values were 155.44 ± 42.69, 152.2 ± 32.82; HDL values were 45.46 ± 5.02, 46.64 ± 5.32; and LDL values were 124.43 ± 42.45, 119.75 ± 39.99 respectively in the subclinical hypothyroidism and overt hypothyroidism. CONCLUSION In overt hypothyroid group, TSH showed statistically significant positive correlation with total cholesterol (r= 0.434, p < 0.0164), Triglyceride (r= 0.339, p < 0.05) and LDL cholesterol (r= 0.409, p < 0.05). TSH had negative correlation with HDL cholesterol (r= -0.394, p < 0.05). In Subclinical hypothyroid group, TSH showed statistically significant correlation with total cholesterol (r= 0.387, p < 0.05), LDL-C (r= 0.404, p < 0.05). The correlation between TSH was statistically not significant for Triglyceride, VLDL and HDL-C. No direct correlation was found between TSH levels and degree of dyslipidaemia. The study has demonstrated and has further proved that hypothyroidism also causes significant dyslipidaemia in subclinical hypothyroidism.
doi:10.14260/jemds/2018/62 fatcat:7goey66akbhkpcxegt2ojzhzii