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Faculty of 1000 evaluation for Role of tet1/3 genes and chromatin remodeling genes in cerebellar circuit formation
[dataset]
2018
F1000 - Post-publication peer review of the biomedical literature
unpublished
Although mechanisms underlying early steps in cerebellar development are known, evidence is lacking on genetic and epigenetic changes during the establishment of the synaptic circuitry. Using metagene analysis, we report pivotal changes in multiple reactomes of epigenetic pathway genes in cerebellar granule cells (GCs) during circuit formation. During this stage, Tet genes are up-regulated and vitamin C activation of Tet enzymes increases the levels of 5hydroxymethylcytosine (5hmC) at exon
doi:10.3410/f.726044443.793552037
fatcat:ntejim3xxfhmpaclobp6uzpsve