Effect of chronic inflammation inhibition with salsalate on aortic stiffness and vascular endothelial function in older adults: A randomized controlled study

Gary Pierce, Lyndsey DuBose, Amy Stroud, Nicholas Jensen, Lauren Wegman-Points, Seth Holwerda, William Haynes, Kaitlyn Dubishar, Jess Fiedorowicz
2017 Artery Research  
Intraaortic balloon counterpulsation (IABP) is a method of temporary mechanical circulatory support in patients suffering from cardiogenic shock to improves the balance of myocardial oxygen supply and demand by using systolic unloading and diastolic augmentation. Arteriograph is an invasively validated oscillometric device which measures central blood pressure (SBPao) noninvasively. The recently developed Arteriograph24 is a combination of a 24-hour BPmonitor and a single-measurement
more » ... h which provides both 24hour peripherial and central BP profile. Comparison of simultaneous invasive measurements by IABP and noninvasive ones by Arteriograph of SBPao was never published yet. Aim: The aim of this work was to compare the SBPao values measured with these two modalities. Subjects and method: 11 severely ill patients placed on IABP were included into this study. Noninvasive monitoring of SBPao was carried out by Arterio-graph24 simultaneously with IABP. Descriptive statistics were calculated for both measurements and the variables were indicated as means and standard deviations. Linear regression analysis was carried out to define the relationship between the invasive and noninvasive variables. Results: A strong and linear correlation was found between the invasive and non-invasive SBPao values, Pearson's correlation coefficient was R Z 0.76; p < 0.001. The diastolic counterpulsation pressure waves could be correctly identified on Arteriograph-registrations. Furthermore, the onset and the end of counterpulsation were also exactly defined noninvasively. Conclusions: The noninvasive SBPao values showed strong correlation with invasive values. Our results confirm that the SBPao values, measured by Arteriograph, are close to the true aortic SBP. This is the first investigation when Arteriograph24 is validated againts invasive SBPao measurement by IABP. Background: Aortic valve stenosis (AS) is common in the elderly and is associated with high morbidity and mortality, and leads to functional decline. The aim of this study was to investigate the possible relation between aortic stiffness, AS and frailty in older patients undergoing Transcatheter Aortic Valve Implantation (TAVI). Methods: TAVI Care&Cure is an observational ongoing study including consecutive patients undergoing TAVI procedure at the Erasmus University Medical Center. Prior to TAVI echocardiography was performed and aortic stiffness was measured non-invasively by the Mobil-O-Graph. The frailty status was assessed including 5 domains. Primary outcome was to investigate the relationship between structural and functional cardiovascular parameters and frailty status. Linear regression was used. Results: A total of 212 patients were included for analysis. Mean age was 79,2 years (AE7,8), 52,7% men, mean Aortic Valve Area (AVA) was 0,73 (AE 0,3),
doi:10.1016/j.artres.2017.10.132 fatcat:vowtt2pnifgkrfbhkzlczqmzgq