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Postischemic Recovery of Contractile Function is Impaired in SOD2+/- but Not SOD1+/- Mouse Hearts
2002
Circulation
Background-Reactive oxygen species (ROS) contribute to myocardial stunning. Superoxide dismutase (SOD) is a major defense mechanism against ROS. The purpose of this study was to evaluate the contributions of cytosolic (SOD1) and mitochondrial (SOD2) isoforms to protect against myocardial stunning. Methods and Results-Isolated hearts from wild-type, heterozygous (ϩ/Ϫ) SOD1 and SOD2 knockout mice received 30 minutes of ischemia followed by 60 minutes of reperfusion. After 60 minutes of
doi:10.1161/hc0802.104502
pmid:11864929
fatcat:rvwirnptdvdahmz7omjetxsscq