and pulse and respiration were accelerated. The symp¬ toms progressed gradually and death resulted from as¬ thenia. Only on the day of death did the urine contain a trace of albumin. On post-mortem examination the muscular tissue in places presented a brownish-red appearance, with punc¬ tate and linear pigmentation, and in other places a waxy-yellow appearance. The pericardium contained an excess of turbid fluid. The epicardium over the left ventricle contained a considerable number of small