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Synthetic Studies on (+)-Biotin, Part 15: A Chiral Squaramide-Mediated Enantioselective Alcoholysis Approach toward the Total Synthesis of (+)-Biotin
2011
Chemical and pharmaceutical bulletin
Over the past two decades, significant progress in organocatalysis has been achieved by mark advances in the enantioselective desymmetrization of meso and other prochiral compounds. Well known in the respect is the catalytic asymmetric desymmetrization of meso-cyclic anhydride via the addition of an alcohol nuclophile, which represents a simple and elegant method for the preparation of synthetically pliable hemiester with the generation of either single or multiple stereocenters with high
doi:10.1248/cpb.59.488
pmid:21467680
fatcat:w7pyqjkz2zgmxgkbh4psrnp72y