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A Single, Bi-functional Aquaglyceroporin in Blood-stagePlasmodium falciparumMalaria Parasites
2001
Journal of Biological Chemistry
The malaria parasite Plasmodium falciparum faces drastic osmotic changes during kidney passages and is engaged in the massive biosynthesis of glycerolipids during its development in the blood-stage. We identified a single aquaglyceroporin (PfAQP) in the nearly finished genome of P. falciparum with highest similarity to the Escherichia coli glycerol facilitator (50.4%), but both canonical Asn-Pro-Ala (NPA) motifs in the pore region are changed to Asn-Leu-Ala (NLA) and Asn-Pro-Ser (NPS),
doi:10.1074/jbc.m110683200
pmid:11729204
fatcat:cbxo4nh55bedpchc5yibygrl3y