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Alignment-free sequence comparison--a review
2003
Bioinformatics
Motivation: Genetic recombination and, in particular, genetic shuffling are at odds with sequence comparison by alignment, which assumes conservation of contiguity between homologous segments. A variety of theoretical foundations are being used to derive alignment-free methods that overcome this limitation. The formulation of alternative metrics for dissimilarity between sequences and their algorithmic implementations are reviewed. Results: The overwhelming majority of work on alignmentfree
doi:10.1093/bioinformatics/btg005
pmid:12611807
fatcat:n5nv22jgwvbhtphlzts3j54xty