Association between Aldehyde Dehydrogenase-2 Gene Polymorphisms and Consumption of Alcohol in the Precursor Lesions of Esophageal Squamous Cell Carcinoma

Takashi MURAMOTO, Kazuhiro KANEKO, Kazuo KONISHI, Hisako NOZAWA, Atsushi KATAGIRI, Yutaro KUBOTA, Yuichiro YANO, Yoshiya KOBAYASHI, Miki KUSHIMA, Michio IMAWARI
2009 The Showa University Journal of Medical Sciences  
The genetic polymorphisms of aldehyde dehydrogenase-2 ALDH2 affect the metabolism of alcohol. The inactive ALDH2 1/2 2 heterozygote genotype increases the risk of esophageal squamous cell carcinoma because of accumulation of acetaldehyde. The aim of this prospective study was to investigate whether daily alcohol consumption and the genetic polymorphisms of ALDH2 were risk factors for esophageal squamous intraepithelial neoplasia, as low-grade intraepithelial neoplasia LGIN is considered to be
more » ... initial lesion of esophageal squamous cell carcinoma. Lugol chromoendoscopy was performed in 400 subjects at Showa University Hospital from January 2004 to August 2008. The effects of smoking, alcohol consumption, and ALDH2 genotype were evaluated in subjects with high-grade intraepithelial neoplasia HGIN , LGIN, and controls without neoplasia. Of the 400 subjects, 32 8 had HGIN, 21 5 had LGIN, and 347 87 were controls. There were no signi cant differences in the proportion of male subjects, or the prevalence of smoking, drinking, or the ALDH2 1/2 2 genotype between LGIN subjects and controls. In contrast, the prevalence of ALDH2 1/2 2 was signi cantly higher in HGIN 24/32, 75 than in LGIN subjects 8/21, 38 ; P 0.007 . Furthermore, the prevalence of alcohol consumption plus ALDH2 1/2 2 differed signi cantly between HGIN 20/25, 80 and LGIN 3/12, 25 ; P 0.001 , while there was no signi cant difference between LGIN and controls. Daily alcohol consumption and the ALDH2 1/2 2 genotype were not risk factors for LGIN, however, alcohol consumption was a high-risk factor for HGIN in subjects with ALDH2 1/2 2.
doi:10.15369/sujms.21.67 fatcat:vkdfjk2mvvf6jcbsomsv7p6rn4