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The evolution of complex gene regulation by low-specificity binding sites
2013
Proceedings of the Royal Society of London. Biological Sciences
Transcription factor binding sites vary in their specificity, both within and between species. Binding specificity has a strong impact on the evolution of gene expression, because it determines how easily regulatory interactions are gained and lost. Nevertheless, we have a relatively poor understanding of what evolutionary forces determine the specificity of binding sites. Here we address this question by studying regulatory modules composed of multiple binding sites. Using a population-genetic
doi:10.1098/rspb.2013.1313
pmid:23945682
pmcid:PMC3757967
fatcat:7mo2it4wc5eu3j6ox4p45rcrf4