ANTIOXIDANT STATUS AND LIPID PROFILE IN RELATION TO GLYCOSYLATED HEMOGLOBIN LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS
English

Jeevan K Shetty, Prasiddha Tilak, Mahesh S Shetty, Naureen Anwar, Mungli Prakash
2015 Journal of Evolution of Medical and Dental Sciences  
OBJECTIVE: Type 2 Diabetes Mellitus (Type 2 DM) is a metabolic disorder related to either insulin deficiency or resistance. Glycosylated haemoglobin (HbA1c) is used to monitor long term regulation of blood glucose. Studies relating HbA1c with antioxidant status and lipid profile are very few. Present study was carried out to determine the relation between HbA1c and antioxidant markers along with lipid profile in these patients. METHODOLOGY: Blood samples were collected from healthy controls
more » ... 5) and type 2 DM patients (n=52) and their fasting lipid profile and HbA1c levels were determined using auto analyser. Antioxidant status markers such as serum thiols, ceruloplasmin and GST were measured spectrophotometrically. RESULT: There was significant increase in fasting plasma glucose (FPG) (p<0.001), HbA1c (p<0.001), LDL-C (p<0.001) and ceruloplasmin (p<0.001), and there was significant decrease in serum total antioxidant status (p<0.001), total thiols (p<0.001), GST (p<0.001), and HDL-C (p<0.001) in type 2 DM patients compared to healthy controls. HbA1c correlated positively with FPG (r=0.749, p<0.001), LDL-C (r=0.513, p<0.001) and negatively with HDL-C (r=-0.715, p<0.001), total thiols (r=-0.704, p<0.001) and GST (r=-0.426, p<0.001). CONCLUSION: Findings in our study support the fact that increased glycation of biomolecules and enhanced generation of free radicals lead to deficient antioxidant status coupled with altered lipid profile may possibly increase the susceptibility to atherogenesis.
doi:10.14260/jemds/2015/2036 fatcat:fcoxqht2azcyhbhrkbpi7a36qq