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ER-targeted Intrabodies Mediating Specific In Vivo Knockdown of Transitory Proteins in Comparison to RNAi
[chapter]
2016
RNA Interference
In animals and mammalian cells, protein function can be analyzed by nucleotide sequence-based methods such as gene knockout, targeted gene disruption, CRISPR/Cas, TALEN, zinc finger nucleases, or the RNAi technique. Alternatively, protein knockdown approaches are available based on direct interference of the target protein with the inhibitor. Among protein knockdown techniques, the endoplasmic reticulum (ER) intrabodies are potent molecules for protein knockdown in vitro and in vivo. These
doi:10.5772/62103
fatcat:6g5ach3fczgtbaphld37becuye