A Novel Histopathological Evaluation Method Predicting the Outcome of Non-small Cell Lung Cancer Treated by Neoadjuvant Therapy: The Prognostic Importance of the Area of Residual Tumor

Yuki Yamane, Genichiro Ishii, Koichi Goto, Motohiro Kojima, Masayuki Nakao, Yoshihisa Shimada, Yutaka Nishiwaki, Kanji Nagai, Hirotsugu Kohrogi, Atsushi Ochiai
2010 Journal of Thoracic Oncology  
Histopathological evaluation method for predicting the outcome of non-small cell lung cancer (NSCLC) treated by neoadjuvant therapy has not been fully assessed. The purpose of this study was to assess a novel histopathological evaluation method for predicting the outcome of NSCLC treated by neoadjuvant therapy. Methods: We reviewed the histopathology of the tumors of 53 NSCLC treated by neoadjuvant chemotherapy, chemoradiotherapy, or radiotherapy followed by complete resection and identified
more » ... histologic features produced by neoadjuvant therapy by comparing them with the histologic features of the tumors in 138 NSCLC cases treated by surgery without neoadjuvant therapy. We also measured the area of residual tumor (ART) on the maximum cut surface of the tumors and analyzed the relationships between the histologic features, ART, and the outcome. Results: The proportions of cases with the histologic features "cholesterin clefts," "foreign body reactive giant cells," "stromal hyalinosis," and "bizarre nucleus in more than 50% of the cancer cells" were significantly higher in the neoadjuvant therapy group than in the surgery alone group. However, the presence of none of these features had any significant effect on survival. Although pathologic T factor and N factor had no significant effect on overall survival, smaller ART (Յ400 mm 2 ) and absence of pleural invasion (p [Ϫ]) were predictors of a outcome (p ϭ 0.014 and p ϭ 0.003, respectively). Conclusions: Smaller ART and p (Ϫ) predict a better outcome of NSCLC treated by neoadjuvant therapy. We concluded that ART is a novel histopathological evaluation method for predicting the outcome of NSCLC treated by neoadjuvant therapy.
doi:10.1097/jto.0b013e3181c0a1f8 pmid:20035185 fatcat:yrpi67wkpjgk5e3brq4dxr7o7u