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Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock
2019
Nucleic Acids Research
The non-canonical initiation factor DENR promotes translation reinitiation on mRNAs harbouring upstream open reading frames (uORFs). Moreover, DENR depletion shortens circadian period in mouse fibroblasts, suggesting involvement of uORF usage and reinitiation in clock regulation. To identify DENR-regulated translation events transcriptome-wide and, in particular, specific core clock transcripts affected by this mechanism, we have used ribosome profiling in DENR-deficient NIH3T3 cells. We
doi:10.1093/nar/gkz261
pmid:30982898
pmcid:PMC6547434
fatcat:zh5brwttzjbu7oizf4na7t4c2a