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The BDNF Val66Met Polymorphism Modulates Sleep Intensity: EEG Frequency- and State-Specificity
2012
Sleep
EEG slow waves are the hallmark of deep NREM sleep and may reflect the restorative functions of sleep. Evidence suggests that increased sleep slow waves after sleep deprivation reflect plastic synaptic processes, and that brain-derived neurotrophic factor (BDNF) is causally involved in their homeostatic regulation. The functional Val66Met polymorphism of the gene encoding pro-BDNF causes impaired activity-dependent secretion of mature BDNF protein. We investigated whether this polymorphism
doi:10.5665/sleep.1690
pmid:22379239
pmcid:PMC3274334
fatcat:wlojhatzmrdqjfhmvpoddx5bgy