Sickle cell diseases are inherited hematological diseases, prevalent in certain parts of the world. We report two cases of sickle cell diseases, first being sickle cell β β-thalassaemia and second homozygous sickle cell disease (SS). Our first case was 5 year old boy presenting with hemolytic anaemia & hepatosplenomegaly having sickle cell β β-thalassaemia disease. Second case was 17 years female presenting with hemolytic anaemia & joint pain having homozygous sickle cell disease.