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A highly accurate platform for clone-specific mutation discovery enables the study of active mutational processes
2020
eLife
Bulk whole genome sequencing (WGS) enables the analysis of tumor evolution but, because of depth limitations, can only identify old mutational events. The discovery of current mutational processes for predicting the tumor's evolutionary trajectory requires dense sequencing of individual clones or single cells. Such studies, however, are inherently problematic because of the discovery of excessive false positive mutations when sequencing picogram quantities of DNA. Data pooling to increase the
doi:10.7554/elife.55207
pmid:32255426
pmcid:PMC7228773
fatcat:dqookwnm6veihiy3w46vycuzz4