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Rqc2 levels alter CAT tail composition, function, and toxicity in S. cerevisiae
The Ribosome-associated Quality Control (RQC) pathway targets incomplete polypeptides from stalled translation for degradation. The primary route of degradation involves ubiquitylation of ribosome-tethered incomplete polypeptides by the E3 ligase Ltn1. To safeguard cells from Ltn1 failure, the protein Rqc2 directs the ribosome to append incomplete polypeptides with carboxy-terminal alanine and threonine residues (CAT tails) that act as degrons, marking RQC-evading polypeptides for degradation.doi:10.1101/687319 fatcat:5kcm5ufroffspkp3s4t5nuqao4