Kinetics of Procalcitonin in the Management of Small Bowel Obstruction: A Preliminary Report

Sabbagh C Cosse C
2013 Surgery: Current Research  
The PCT kinetics' study participants were divided into two groups: patients in whom the CM was successful (the CM group, n=47) and those in whom it had failed (the SM group, n=12). Abstract Background: Small Bowel Obstruction (SBO) is mainly due to adhesions acquired after abdominal surgery. Its management could be conservative or surgical but the choice is difficult because of the absence of clinico-biological markers. Serum procalcitonin (PCT) has previously been proposed as a biomarker. The
more » ... im was to present the kinetics' profiles of serum PCT in cases of Conservative Management (CM) success and surgical management (SM) in patients with SBO. Study design: From January to October 2013, 59 patients with adhesion-related SBO were included in a prospective, monocenter, non-randomized, clinical study. PCT was measured during 3 days maximum (or until the transit was restored), every six hours. The patients were divided into subgroups (conservative (CM) and surgical management (SM)). The predictive time points were identified with ROC curves. (n=47) presented at admission a lower PCT and a higher chloride than in the SM group (n=12) (p<0.003). The time points of PCT for predicting SM are at admission (threshold>0.165 ng/mL; sensitivity (Se)=83.3% and negative predictive value (NPV)=93%), 18 hours after admission (threshold >0.275 ng/mL; Se=100% and NPV=100%) and 24 hours after admission (threshold>0.255 ng/mL; Se=83.3% and NPV=95%). Results; Patients in CM group Conclusion: PCT is helpful in SBO's management. The more predictive time points are at admission, 18 hours and 24 hours after admission to identify the patients requiring surgery. Sur g e ry : Cu rrent R e s e ar ch
doi:10.4172/2161-1076.1000184 fatcat:t3rfsrqavnhrflohxe7d6vkjae