In-situ Patterning of Magnetic Particles in Microfluidic Channels by Forward/Reverse Local Magnet Arrangement
국소 자기장의 순/역 배열을 이용한 미세유체 채널 내에서의 강자성 입자 패턴 형성

Hyoun-Hyang Park, Ji Hae Lee, Yeong Eun Yoo, Jung-Yup Kim, Sunghwan Chang
2015 Transactions of the KSME C Industrial Technology and Innovation  
1. 서 론 마이크로, 나노 공학이 발달하면서 자성 미세입자의 응용이 바이오 분야를 비롯하여 미세 유체 조건에서의 적용 분야에서도 높아지고 있다. (1,2) 특히 면역측정법에서는 자성 미세 입자를 단백질이나 세포에 결합 시켜 검 출 시간을 단축시키고, 검출 민감도를 높이는 데 사용하고 있어, 그 응용 기술 개발이 지속적으로 이루어 지고 있다. (3) 따라서 자기력을 기반으로 한 미세입자 포획을 위한 효과적인 방법을 개발하는 것은 중요한 응용기술의 방향 중 하나라고 판단 된다. Abstract: The patterning of microbead in microfluidics channel is a practical technique for application in bio and medical areas. An approach is described for a direct patterning of magnetically active microbeads in microfluidic
more » ... s in microfluidic devices without inner structure. Local magnet arrangements -flat arrangement and stack arrangement -contacting same poles or opposite poles of magnet were utilized for generating trapping magnetic fields. The arrangement of magnets contacting same poles generated isolated patterns by repelling of magnetic field. The flat arrangement of vertically reverse magnet arrays shaped trapping patterns repelling magnetic field line between same poles. Spatially, the stack compositions of magnet arrangements allow diverse isolated trapped patterns of magnetic particles. Trapped magnetic particles in fluidic channels were stable on the 18 ㎖/hr flow conditions and magnetic force of 1.08 mT in the all experiments. This experimental study suggests the simple and versatile methods to pattern magnetic particles, and has potential of wide application to bio and medical area.
doi:10.3795/ksme-c.2015.3.3.217 fatcat:oueyfjb33fdurk4uc3iv3xq5hu