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Calcification of bioprosthetic valves (BVs) implanted in aortic position can result in gradual deterioration and necessitate aortic valve replacement. The molecular mechanism of calcium deposition on BV leaflets has been investigated, but remains to be fully elucidated. The present study aimed to identify explanted bioprosthetic valve (eBV)specific proteins using a proteomics approach and to unveil their biochemical and histological involvements in calcium deposition on BV leaflets.doi:10.1242/bio.034009 pmid:30089611 fatcat:xq7hvaqdpradzjfu2z6fvzmgtq