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Artificial intelligence method to design and fold alpha-helix structural proteins from the primary amino acid sequence
[article]
2019
bioRxiv
pre-print
AbstractWe report an artificial intelligence (AI) based method to predict the molecular structure of proteins, focused here on an important subclass of proteins dominated by alpha-helix secondary structure, as found in many structural biomaterials such as keratin and membrane proteins. Fast yet accurate predictions of an unknown protein's 3D all-atom structure can yield a pre-screened set of candidate proteins to be investigated further via large-scale protein expression in bacteria or yeast.
doi:10.1101/660639
fatcat:e3skeu5emzdkddftkrycjuimue