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Inhibition of Protein Fibrillation by Hydrogen Sulfide
[chapter]
2019
Amyloidosis [Working Title]
Amyloid fibrils are misfolded proteins, which are often associated with various neurodegenerative diseases such as Alzheimer's. The amount of hydrogen sulfide (H 2 S) is known to be reduced in the brain tissue of people diagnosed with Alzheimer's disease relative to that of healthy individuals. Hen Egg-White Lysozyme (HEWL) forms typical β-sheet-rich fibrils during 70 minutes at low pH and high temperatures. These results are consistent with the ThT findings that β-sheets structure is also
doi:10.5772/intechopen.86221
fatcat:4sc7eukjcfd7dcyeqqzupgazr4