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CryoEM and computer simulations reveal a novel kinase conformational switch in bacterial chemotaxis signaling
Chemotactic responses in bacteria require large, highly ordered arrays of sensory proteins to mediate the signal transduction that ultimately controls cell motility. A mechanistic understanding of the molecular events underlying signaling, however, has been hampered by the lack of a high-resolution structural description of the extended array. Here, we report a novel reconstitution of the array, involving the receptor signaling domain, histidine kinase CheA, and adaptor protein CheW, as well asdoi:10.7554/elife.08419 pmid:26583751 fatcat:lserwqslkzasvff3khuclrbgsq