tRNAscan-SE On-line: integrating search and context for analysis of transfer RNA genes

Todd M. Lowe, Patricia P. Chan
2016 Nucleic Acids Research  
High-throughput genome sequencing continues to grow the need for rapid, accurate genome annotation and tRNA genes constitute the largest family of essential, ever-present non-coding RNA genes. Newly developed tRNAscan-SE 2.0 has advanced the stateof-the-art methodology in tRNA gene detection and functional prediction, captured by rich new content of the companion Genomic tRNA Database. Previously, web-server tRNA detection was isolated from knowledge of existing tRNAs and their annotation. In
more » ... is update of the tRNAscan-SE On-line resource, we tie together improvements in tRNA classification with greatly enhanced biological context via dynamically generated links between web server search results, the most relevant genes in the GtRNAdb and interactive, rich genome context provided by UCSC genome browsers. The tRNAscan-SE On-line web server can be accessed at http://trna.ucsc.edu/tRNAscan-SE/.
doi:10.1093/nar/gkw413 pmid:27174935 pmcid:PMC4987944 fatcat:x4grpmkearfebiojfqyyikxmvm