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Sustainable Development Goals set a challenge for the elimination of hepatitis B virus (HBV) infection as a public health concern by the year 2030. We here set out to evaluate the current and future role of HBV vaccination and prevention of mother to child transmission (PMTCT) as tools for elimination, through the combined scrutiny of a paediatric cohort in South Africa and a new model to simulate transmission and prevention. Existing efforts have been successful in reducing prevalence ofdoi:10.1101/162594 fatcat:kq27w2bid5akrbnjk4v6z3ximq