1] Premature gonadal failure [2] Premature ovarian failure [3] Familial premature ovarian failure [4] Evidence for a genetic factor in the etiology of premature ovarian failure [5] Molecular cytogenetic studies of Xq critical regions in premature ovarian failure patients [6] Premature ovarian failure (POF) syndrome: Towards the molecular clinical analysis of its genetic complexity [7] An X;9 translocation, primary amenorrhea, and hypothalamic dysfunction [8] Balanced reciprocal (X;9)

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... on in a girl with primary amenorrhea [9] New syndrome of amenorrhea in association with hypergonadotropism and apparently normal ovarian follicular apparatus [10] The gonadotropin resistant ovary syndrome [11] Premature menopause due to a small deletion in the long arm of the X chromosome: A report of three cases and a review [12] Hypergonadotropichypogonadism in female patients with galactosemia [13] Three siblings with premature gonadal failure [14] Investigating the role of X chromosome breakpoints in premature ovarian failure [15] Cytogenetic analysis of 531 Chinese women with premature ovarian failure [16] Genetic abnormalities in Turkish women with premature ovarian failure [17] A study of hypergonadotropic secondary amenorrhea with cytogenetics [18] The cytogenetics of premature ovarian failure [19] Chromosome mosaicism in patients with recurrent abortion or premature ovarian failure Patients Information Considering the clinical importance and the deep impact of Premature Ovarian Failure (POF) on the life of affected people and the important role of genetics in its development, this study was conducted to determine the frequency and type of chromosomal abnormalities in Iranian women referred to Sarem Hospital with premature ovarian failure. Karyotype analysis and its association with phenotype were performed on 13 Iranian women with confirmed premature ovarian failure. The metaphase chromosomes were prepared and analyzed with G-bonding technique and mosaicism of 100 cells from lymphocyte cells was studied. Finally, chromosomal abnormalities were diagnosed in 2 of 13 patients (15.38%) with premature ovarian failure. A patient with chromosomal mosaicism was [42] XX, 46 / [8] X, 45. The second patient had a translocation between chromosome X and chromosome 9, that was 46, XX, t(X,9)(q22.1;q22,1). Conclusion The overall prevalence of chromosomal abnormalities is 15.38% among patients with premature ovarian failure, which is confirmed by our findings in the chromosomal examination of these women.