Protective Effect of Sauchinone on Methamphetamine-Induced Neurotoxicity in Mice

Eun Young Jang, Kyung Ah Park, Jong Rock Lee, Chae Ha Yang, Meeyul Hwang
2012 Journal of Pharmacological Sciences  
Sauchinone is a lignan isolated from Saururus chinensis known to suppress nitric oxide (NO) activity. Previous studies demonstrate that NO plays a key role in methamphetamineinduced neurotoxicity. Thus, we hypothesized that sauchinone could have a suppressive effect on the neurotoxicity induced by methamphetamine. Repeated injections of methamphetamine cause degeneration of dopaminergic nerve terminals, whereas sauchinone treatment significantly prevented this degeneration. Sauchinone treatment
more » ... also inhibited the methamphetamine-induced activation of glia cells and the production of NO via a blockade of inducible NO synthase protein expression. Our results suggest that sauchinone can prevent methamphetamine-induced neurotoxicity through the suppression of NO production.
doi:10.1254/jphs.11207sc pmid:22510968 fatcat:loonbqtby5euzl4lwjke5anyzq