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Feasibility of imaging synaptic density in the human spinal cord using [11C]UCB-J PET
2022
EJNMMI Physics
Purpose Neuronal damage and synapse loss in the spinal cord (SC) have been implicated in spinal cord injury (SCI) and neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS). Current standards of diagnosis for SCI include CT or MRI imaging to evaluate injury severity. The current study explores the use of PET imaging with [11C]UCB-J, which targets the synaptic vesicle protein 2A (SV2A), in the human spinal cord, as a way to visualize synaptic density and integrity in vivo.
doi:10.1186/s40658-022-00464-0
pmid:35503134
pmcid:PMC9065222
fatcat:g6ghkjnblja2lj27b6k2gddqhq