The underlying pathomechanisms of delayed wound healing in patients with diabetes mellitus is still a frequent and very severe problem. From a holistic point of view however, contemporary management of chronic wounds attempts to improve natural healing and individualization of treatment. Herein, we report an effective usage of platelet-rich plasma (PRP), both subcutaneously and topically, in combination with an optimized glycemic control diet in a chronic and nonhealing wound. Over 26 weeks, a

more »

... atient diagnosed with diabetes mellitus had received multiple therapies in attempt to heal a severe leg wound. The introduction to PRP therapy and the daily usage of the PRP gel topically led to an approximately 30% reduction in wound size over 12 days. Optimization of the patient's diet was eventually added to the treatment protocol after seeing the first improvement in wound healing. A weight loss was observed during the treatment period from 105 kg pre-treatment to 88 kg post-treatment, respectively. The prompt and promising outcome of this protocol indicates hope for the patients with chronic wounds and the urge of the further studies with holistic approaches.