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The synaptic vesicle protein Synaptotagmin I is the calcium ion sensor for neurotransmitter release. Synaptotagmins are comprised of C2 domains, calcium ion dependent, membrane-binding domains. They contain multiple C2 domains and all C2 domains are tethered to the membrane. Our recent workdoi:10.1016/j.bpj.2014.11.2895 fatcat:ags2qdfu6bhkfcyks37vwgyh7q